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KMID : 0369820170470050395
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Jorunal of Korean Pharmaceutical Sciences
2017 Volume.47 No. 5 p.395 ~ p.411
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Development, optimization and pharmacodynamic assessment of olanzapine based lipidic SNEDDS for proficient management of psychosis
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Ahsan Mohd Neyaz
Verma Priya Ranjan Prasad
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Abstract
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The purpose of this study was to demonstrate the use of 32 factorial design for the development and optimization of lipid based self nanoemulsifying drug delivery system of olanzapine using response surface methodology and to establish a functional relationship between two operating variables of Acconon E (X1) and Cremophor EL (X2). The response variables selected were optical clarity in Millipore water (Y1), Particle size in Millipore water (nm) (Y2), Particle size in 0.1 N HCl (nm) (Y3), Particle size in PB 7.4 pH (nm) (Y4), emulsification time (sec) (Y5) and time for 85 % of drug released (T85 %) (Y6). Compatibility studies using the fourier transform infrared spectroscopy, differential scanning calorimeter and X-ray diffraction studies indicated absence of any incompatibility between olanzapine and excipients used to prepare SNEDDS. Transmission electron microscopy of optimized formulations demonstrated the spherical globules morphology with no signs of coalescence and precipitation of drug. The in vitro hemolysis study and histological study showed the nondamaging effect of the OLZ-SNEDDS. Pharmacodynamic evaluation (Behavioural study) indicates better efficacy of olanzapine loaded SNEDDS.
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KEYWORD
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Olanzapine, Self nanoemulsifying drug delivery, Factorial design, Response, Surface methodology, Transmission electron microscopy, In vitro hemolysis, Behavioural study
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